News

Cancer has a biological clock, and this drug may keep it from ticking

Published

on

‘);
} else {
$(“.fotorama-caption”).addClass(“remove_caption”);
}
})
.fotorama();

A new drug shows potential to halt cancer cells’ growth by stunting the cells’ biological clock.

The findings from scientists at USC Michelson Center for Convergent Bioscience, and Nagoya University’s Institute of Transformative BioMolecules (ITbM) advance a burgeoning area of research — turning the body’s circadian rhythms against cancer.

Their study, conducted on human kidney cancer cells and on acute myeloid leukaemia in mice, was published January 23, 2019 in the journal Science Advances.

Scientists know that disrupting sleep and other elements of humans’ circadian rhythm can harm health. The same is true for the circadian clock of cells themselves. If researchers could disturb the circadian clock of cancer cells, they theorise, they could potentially hurt or kill those cells.

The scientists found that a molecule named GO289 targets an enzyme controls the cell’s circadian rhythm. This drug-protein interaction then disrupts the functions of four other proteins that are important for cell growth and survival.

In effect, GO289 can jam the cogs of the cell’s circadian clock, slowing its cycles. And it can do so with little impact to healthy cells.

“In some cancers, the disease takes over the circadian clock mechanism and uses it for the evil purpose of helping itself grow,” said Steve Kay, director of convergent biosciences at USC Michelson Center and USC Provost professor of neurology, biomedical engineering and biological sciences. “With GO289, we can interfere with those processes and stop the cancer from growing.”

Kay is among several scientists from USC Dornsife College of Letters, Arts and Sciences, USC Viterbi School of Engineering, and Keck School of Medicine at USC who are collaborating across multiple disciplines to find new solutions for treating cancer, neurological disease and cardiovascular disease.

 

Finding the right candidate

On its initial interactions with human bone cancer cells, GO289 appeared to slow the tumours’ circadian clock as it targeted an enzyme, named CK2.

To see if GO289 consistently hindered other cancers in the same way, the scientists then tested it on human kidney cancer cells and on mice with acute myeloid leukaemia. They found that GO289 specifically affected cancer cell metabolism and other circadian-related functions that normally would enable the cancer to grow and spread.

Kay is optimistic about the findings. “This could become an effective new weapon that kills cancer,” he said.

 

Source link

قالب وردپرس

News

Over 30 sanctioned for not wearing masks in Mandeville

Published

on

By



























Over 30 sanctioned for not wearing masks in Mandeville





























































Copyright © 2020 Jamaica Observer. All Rights Reserved.

Terms under which this service is provided to you.
















Source link

قالب وردپرس

Continue Reading

News

1.5m health-care workers in Latin America, Caribbean fully vaccinated

Published

on

By



























1.5m health-care workers in Latin America, Caribbean fully vaccinated





























































Copyright © 2020 Jamaica Observer. All Rights Reserved.

Terms under which this service is provided to you.
















Source link

قالب وردپرس

Continue Reading

News

Ministry points to danger of vaccine hesitancy among high-risk groups

Published

on

By



























Ministry points to danger of vaccine hesitancy among high-risk groups





























































Copyright © 2020 Jamaica Observer. All Rights Reserved.

Terms under which this service is provided to you.
















Source link

قالب وردپرس

Continue Reading

News

Jamaicans head list of Caribbean people heading to Canada

Published

on

By



























Jamaicans head list of Caribbean people heading to Canada





























































Copyright © 2020 Jamaica Observer. All Rights Reserved.

Terms under which this service is provided to you.
















Source link

قالب وردپرس

Continue Reading

News

Penal partnership

Published

on

By



























Penal partnership





























































Copyright © 2020 Jamaica Observer. All Rights Reserved.

Terms under which this service is provided to you.
















Source link

قالب وردپرس

Continue Reading

popcaan